QuickView for matrix metalloproteinase 14;jsessionid=A00613594403ADC6B00D875F04440A42;jsessionid=2F1668CB406280569390395283F5E7E1 (gene)

Gene Symbol:

Mmp14 Mus musculus

Full name:

matrix metallopeptidase 14 (membrane-inserted)

Synonyms:

AI325305, MMP-X1, MT-MMP-1, MT1-MMP, sabe, matrix metalloproteinase-14, Membrane type 1-MMP, matrix metalloproteinase 14 (membrane-inserted), membrane-type-1 matrix metalloproteinase, type 1 matrix metalloprotease 14

Genomic Location:

Chr 14: 55050456-55060090

Description:

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the en...

View Full Description

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit craniofacial dysmorphism, arthritis, osteopenia, dwarfism, and fibrosis of soft tissues.

View Less

Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RORA2_01 ,  HAND1E47_01 ,  XBP1_01 ,  AML1_01 ,  PAX4_03 ,  EN1_01 ,  VDR_Q3 ,  AP2ALPHA_01 ,  NCX_01 ,  HOXA4_Q2 ,  OSF2_Q6 ,  SREBP1_Q6 ,  AML1_Q6 ,  STAT_Q6 ,  SRF_Q4 ,  GR_Q6_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  TATTATA_MIR374 ,  CTGAGCC_MIR24 ,  TTGGGAG_MIR150 ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  SMTTTTGT_UNKNOWN ,  CAGGTA_AREB6_01 ,  CTTTGT_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  YTATTTTNR_MEF2_02 ,  TGGAAA_NFAT_Q4_01 ,  GGGCGGR_SP1_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410

search → result